Revelation 16:21: And there fell upon men a great hail out of heaven, every stone about the weight of a talent: and men blasphemed God because of the plague of the hail; for the plague thereof was exceeding great.

During the seventh Vial Plague of the Third Woe,¹ a great hail out of heaven will fall² as a divine judgment³ upon all wicked men that still remain on earth.⁴ John mentions the same hailstorm in Revelation 11:19, when he briefly introduced the Third Woe.⁵ This final hailstorm is foreshadowed by‒and is much more severe than‒the hailstorm that will destroy crops when the first trumpet angel of the seventh seal sounds in Revelation 8:7.⁶

The hailstorm of the seventh Vial Plague mirrors the seventh plague in Egypt,⁷ except the Vial Plague will be much worse.⁸ The Lord carried out the Egyptian plague with surgical precision so that the Israelites in Goshen were not injured.⁹ The Lord will use the same surgical precision against the wicked at the Second Coming.¹⁰

The Egyptian plague also included hail mingled with fire.¹¹ John does not mention fire with the hail in his vision of the seventh Vial Plague.¹² Nevertheless, Ezekiel saw the same hailstorm and he said the hail will be mingled with fire in the likeness of Sodom and Gomorrah.¹³ Based on these foreshadows, it's likely that fire will be present with the hail, perhaps as a continuation of the fire from the fourth Vial Plague in Revelation16:8-9.¹⁴ There will also be fire from the glory of Christ's person at his Second Coming.¹⁵

In this final hailstorm at the Second Coming, every stone [will be] about the weight of a talent.¹⁶ Among the Jews in the New Testament, a talent weighed about 100 pounds or more.¹⁷ The weight of the hailstones is a measure of how exceeding great this plague will be.¹⁸ The large hailstones will destroy remaining telestial people in the world that worship the Second Beast,¹⁹ including all people that do not minimally qualify for the terrestrial kingdom.²⁰

The telestial people afflicted by the plague of hail will remain unrepentant,²¹ and will blaspheme God because of the plague.²² That is, they will curse God and die as modern scriptures attest in Doctrine and Covenants Section 45:32.²³ The large hailstones of the seventh Vial Plague are the literal antitype for the ancient practice of stoning people under the Mosaic law when they blasphemed the name of God.²⁴

And there came one of the seven angels which had the seven vials, and talked with me, saying unto me, Come hither; I will shew unto thee the judgment of the great whore that sitteth upon many waters.

— Revelation 17:1